Our team’s work focuses heavily on the impact of photodynamic action on the stroma of solid tumors. More recently, we have also began to focus on the stroma-immune axis to enable more favorable responses to immune checkpoint therapy in pancreatic cancer and head and neck cancer. Our team is achieving this by constructing various iterations of antibody conjugates, lipid nanoparticles (and everything in between) with the primary focus of disrupting the immunosuppressive tumor microenvironment. This talk will describe our team’s efforts to re-engineering photosensitizing systems in order to modulate their photochemistry, and in turn, favor stroma-disrupting and immune enhancing treatment protocols for pancreatic cancer and head and neck cancer.