In recent years, in Limoges lab, we have been developing the design and synthesis of nanoparticles of natural origin for the delivery of photosensitizers (PS) (porphyrins, chlorines, curcumin, etc). These nanoparticles are made from polysaccharides in order to have a hydrophilic character to prevent opsonization by macrophages. In addition, the presence of osidic units on these polysaccharides means that alcohol functions are available and can be functionalized. These nanoparticles, based on dextran, cellulose or hemicellulose, were characterized by TEM, DLS and zeta potential. Recently, cellulose nanoparticles (Cellulose NanoCrystals or CNCs) in needle form have shown very good results for uptake of photosensitizer in different in vitro cancer cell lines and could be a very nice nanoplatform for drug delivery. Preliminary investigations have been realized in vivo with two types of PS/nanoparticles.