The ongoing search for innovative and environmentally friendly luminescent materials with tunable physical and chemical properties at the nanoscale is in high demand. Their unique properties, such as low toxicity, excellent biocompatibility, and tunable cluster-triggered emission luminescence (CLgens) in response to external stimuli, make them ideal probes for biophotonic applications.[1] However, the relationship between the chemical structure of CLgens and their unexpected optical properties is still the missing link to enhance their applications. This study aimed to relate the chemical structure of the newly synthesised CLgens from biomass-derived monomers such as carvone. The spectroscopic studies at steady-state and time-resolved levels help unravel the structure-properties and how this is affected by an external physical stimulus such as temperature and, later, pH. Based on these promising results, and as a proof of concept, the thermal sensitivity was successfully tested at the microscale level to visualise how temperature rises in photothermal methods.[2] So, if the luminescent properties of CLgens do not lack properties previously associated only with traditional chromophores, can they be extrapolated to other types of excited state applications? The real question is: could these excited states transfer energy to oxygen and form reactive oxygen species (ROS)? The preliminary results on the carvone polymers suggest that this is possible and that the long-excited lifetimes could efficiently transfer their excess energy to molecular oxygen to produce ROS such as 1O2. Still, more importantly, they have excellent photoantimicrobial capabilities against Staphylococcus aureus (S. aureus). Therefore, the aggregated results highlight the considerable potential of CLgens as light-emitting materials and mark a crucial turning point in creating a new wave of photosensitizers.